Senior Scientist, Metabolism

Agios Pharmaceuticals (www.agios.com) in Cambridge, Massachusetts, is the first biopharmaceutical company dedicated to drug discovery based on targeting cancer metabolism, which offers the potential for a new class of oncology therapeutics targeting metabolic pathways critical to cancer cell growth, proliferation and survival. With new research showing that cancer cells become addicted to using more nutrients than normal cells to promote their rapid growth, there is an unprecedented opportunity to create a new class of oncology therapeutics that target a fundamental and ubiquitous mechanism in cancer cells. The intersection of these two fields of research - cancer and metabolism- represents an important and novel approach to treating cancer.

Job Responsibilities:

1.Provide scientific leadership at the hands-on experimental and intellectual level for a team of LCMS metabolomic scientists investigating cancer metabolism.
2.Support the coordination, prioritization, and quality control of group experimental activities, spanning research involving animal/xenograft and cell culture samples, and analysis by both triple quadropole and Q-ToF mass spectrometry.
3.Use of established informatics tools for analysis and quantification of complex mixtures of endogenous metabolites, and small molecule therapeutic; interpretation of the results in the context of current literature and in-house metabolic understanding.
4.Fully participate in the communication of analysis results among the scientific team, to senior management, and at scientific meetings and conferences.
5.Interact productively with the cell biology, biochemistry, informatics, and drug development teams at Agios

Qualifications:

1.PhD in any area of the chemical, biological, or biochemical engineering sciences, with a post-doc and 5 years of relevant industry experience (or 7 years without post-doctoral experience) in the area of metabolic research, focusing on LCMS-based experimental methods.
2.Excellent track record of scientific research, supported by refereed publications, patent filings, and public scientific presentations.
3.The ideal candidate will be comfortable working at the interface of physical chemistry and biology, dealing with quantitative physical measurements, and concepts of metabolic flux and chemical potential.
4.Informatic skills a plus, including familiarity with matlab, scripting languages (perl, python), and more generally, aptitude operating within an informatically driven environment.
5. Excellent verbal and written communication skills are required, coupled with an interactive approach to research.

For more information and to apply
please email: job_opportunities@agios.com

Further Information: http://www.agios.com