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Organic azide synthesis in microreactors: from optimization to lab scale production
Pieter J. Nieuwland, Bo Hanssen, Kaspar Koch, Paul Janssen, Marielle M.E. Delville, Anton Lunshof and Floris P.J.T. Rutjes. Radboud University
The formation of benzyl azide by diazotransfer to benzyl amine was screened and subsequently scaled up using continuous flow chemistry.
Microwave chemistry in SiC Reaction Vials
D. Obermayer, B. Gutmann, B. Reichart, C. O. Kappe. University of Graz
Using novel SiC-technology to mimic conventional heated autoclave experiments.
Automated Sample Pretreatment of Environmental
Bernard Sheldon,1 Rosanne Slingsby,1 and Rida Al-Horr2. Dionex Corporation
Matrix elimination is a method of sample preparation that removes
certain matrix species from a sample, typically by specifically binding
matrix species to a solid phase. Interfering compounds can be removed
before the analyte determination, thus improving the quality of results as
well as lengthening the lifetime of consumables such as columns.
Study of volumetric oxygen transfer coefficient in a Taylor vortex flow bioreactor
Patrícia Ap. Santiago, Cláudio A. T. Suazo, Roberto C. Giordano. Federal University of São Carlos
An inadequate transfer of oxygen can lead to rapid changes in cell physiology, metabolism, and cell death. In this work, the KLa is evaluated in a Taylor vortex flow bioreactor and a mass transfer correlation is proposed. The experimental conditions employed were: rotational Reynolds number between 244 and 2928, airflow rates varying from 80 mL.min-1 to 550 mL.min-1 and used culture medium DMEM.
Hyperbaric Bioreactors use with Yarrowia Lipolytica Cultures: Cellular Adaptation to Hyperbaric Conditions
Marlene Lopes, Nelma Gomes, Manuel Mota, Isabel Belo. IBB-Institute for Biotechnology and Bioengineering, Center of Biological Engineering, University of Minho, Braga, Portugal
In this work, a pressurized bioreactor was used for Y. lipolytica batch cultivation under increased air pressure from 1 bar to 6 bar. Cell growth was strongly enhanced by the pressure rise. The increase of oxygen availability caused the induction of the antioxidant enzyme SOD. The pre-growth of Y. lipolytica under increased pressure conditions did not affect the lipase production ability of the cells.
Adaptive control of glycerol & methanol feeding in recombinant Pichia pastoris cultures: Impact on antibody titre
Filipe Ataíde, Ana Raquel Ferreira, João J. Clemente, António E. Cunha, Rui Oliveira. CQFB/REQUIMTE and IBET/ITQB
Pichia pastoris processes for heterolougous protein expression are typically run in three phases: a batch phase, an exponential feeding fed-batch phase and a long oxygen transfer limitation (OTL) phase. The final protein titre is often limited by the oxygen availability in the OTL phase. Here a direct adaptive controller is designed for the OTL phase. The controller was validated in pilot P. pastoris cultivations expressing a single chain antibody fragment (ScFv). This work shows that the propos
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