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Study of volumetric oxygen transfer coefficient in a Taylor vortex flow bioreactor
Federal University of São Carlos
An inadequate transfer of oxygen can lead to rapid changes in cell physiology, metabolism, and cell death. In this work, the KLa is evaluated in a Taylor vortex flow bioreactor and a mass transfer correlation is proposed. The experimental conditions employed were: rotational Reynolds number between 244 and 2928, airflow rates varying from 80 mL.min-1 to 550 mL.min-1 and used culture medium DMEM.
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Hyperbaric Bioreactors use with Yarrowia Lipolytica Cultures: Cellular Adaptation to Hyperbaric Conditions
IBB-Institute for Biotechnology and Bioengineering, Center of Biological Engineering, University of Minho, Braga, Portugal
In this work, a pressurized bioreactor was used for Y. lipolytica batch cultivation under increased air pressure from 1 bar to 6 bar. Cell growth was strongly enhanced by the pressure rise. The increase of oxygen availability caused the induction of the antioxidant enzyme SOD. The pre-growth of Y. lipolytica under increased pressure conditions did not affect the lipase production ability of the cells.
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Drug Delivery, London, England
02 September 2009 - 02 September 2009
The summit includes three one-day symposia on the following subjects: Delivery of Small Molecules & Nucleic Acids, Delivery of Macromolecules and Formulation & Solubility
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Second International Symposium on Combinatorial Sciences, Beijing, China
19 September 2009 - 22 September 2009
The Second International Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials (SCS-09) will feature plenary lectures from: Jim Wells, University of California, San Francisco ;Jon Ellman, University of California, Berkeley; Dennis Curran, University of Pittsburgh, U.S.A.
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Compound Management Trends 2008
Published July 2008
This market report summarizes the results of HTStec’s second global pharma and biotech web-based benchmarking survey on compound management carried out in January 2008.
The study was initiated to gain a better awareness of the metrics behind current and future compound management (CM) practices within pharmaceutical, biotech and other life science research establishments. The survey focus was on liquid stores, with particular emphasis on learning how the makeup of corporate compound collectio
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Cleaning Microreactors
This application note gives hints and tips on cleaning & unblocking flow reactors, i.e. chips or tube based reactors. It is suggested that the whole document is read before attempting to unblock a reactor.
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